ABRAXANE and Advanced Breast Cancer

What should I know about
metastatic breast cancer?

Most common places in the body where MBC may spread.

What is metastatic breast cancer?

Breast cancer is a tumor (TOO-mer) that starts in the breast. A tumor is an abnormal mass of tissue. When a tumor is malignant (muh-LIG-nuhnt), it means that it is cancerous.
When breast cancer spreads from the breast to other parts of the body, it is called metastatic (met-tuh-STA-tik) breast cancer (MBC). This type of cancer is also called advanced or stage 4 breast cancer.

Most common places in the body where MBC may spread.

Most common places where Advanced Breast Cancer may Spread

How many people have metastatic
breast cancer?

If you have MBC, you are not alone:

  • More than 155,000 people in the United States are living with MBC
  • 231,840 new cases of breast cancer are predicted in 2015
  • 30% of women originally diagnosed with early stage breast cancer are estimated to become advanced or metastatic at some point in their lives
  • About 5% of people with breast cancer will be diagnosed with MBC from the start rather than after an early stage diagnosis

Are some people more at risk for breast cancer?

There are certain factors that affect a person’s chance of getting breast cancer. It is important to know that having 1 or more risk factors does not mean that you will definitely get breast cancer. And some people may get this type of cancer even if they don’t have any risk factors.

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Age

Your risk of breast cancer increases as you get older. About 2 out of 3 invasive (in-VEY-siv) breast cancers are found in women aged 55 or older. These are cancers that grow into (invade) normal tissues in or beyond the breast.

Gender

Women are much more likely than men to get breast cancer. It’s 100 times more common in women than men, but it is possible in either gender.

Race

Breast cancer is slightly more common in Caucasian women than in African American women. But African American women are more likely to die of this type of cancer. In younger women (under 45 years of age), breast cancer is more common in African American women. Asian, Hispanic, and Native American women have a lower risk of breast cancer.

Personal or Family History

A woman who has had cancer in one breast is more likely to get a new cancer in the other breast or in another part of the same breast. Women who have a close blood relative with breast cancer are also at greater risk.

Genes

About 5% to 10% of cases are thought to be hereditary (huh-RED-i-ter-ee). This means that the cancer is caused by genetic defects, called mutations (myoo-TEY-shuhns), that are passed on from a parent.

In addition to a person’s age, gender, race, and family history—all things that can’t be changed—there are risk factors for breast cancer that are considered lifestyle factors. This means that they can be controlled to some degree.

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Drinking Alcohol

Compared with nondrinkers, women who have 1 alcoholic drink a day have a slightly higher risk of breast cancer. Women who have 2 to 5 drinks a day have a greater risk.

Weight

Women who are overweight or obese after menopause are at greater risk for breast cancer.

Having Children

Women who have not had children or who had their first child after age 30 are at a slightly higher risk for breast cancer.

Birth Control

Certain forms of birth control put women at greater risk of breast cancer. These include birth control pills and an injectable form of the hormone progesterone that’s given once every 3 months.

Hormone Therapy

Women who take a combination of estrogen and progesterone after menopause to help ease symptoms or prevent osteoporosis (thinning of the bones) are at higher risk for breast cancer.

What is ABRAXANE?

ABRAXANE is a prescription medicine used to treat advanced breast cancer in people who have already received certain other medicines for their cancer.
ABRAXANE is a chemotherapy (KEE-moh-THAYR-uh-pee). Chemotherapy is a type of medicine that is used to keep cancer cells from growing or to kill cancer cells. Treatment with ABRAXANE may help control or slow the spread of cancer cells.
Your doctor may recommend treatment with ABRAXANE based on the stage of your cancer, your response to prior therapy, and your overall health. Only your doctor can help you decide if ABRAXANE is right for you.

What is in ABRAXANE?

The medicine in ABRAXANE,
paclitaxel, is bound to albumin.
Illustrative purposes only.

ABRAXANE is a different formulation of the cancer-fighting medicine paclitaxel (PAK-li-TAK-sel). ABRAXANE is made by binding paclitaxel to albumin (al-BYOO-min). Albumin is a protein found in the blood.

The medicine in ABRAXANE, paclitaxel, is bound to albumin. Illustrative purposes only.

What is in Abraxane for MBC Image

Here is what this means to you:

  • Because ABRAXANE is bound to albumin, no solvents are needed to dissolve it
  • Solvents are chemicals that dissolve some medicines so that they can be given by infusion (in-FYOO-zhun)
  • Some solvents can cause allergic reactions
  • Since ABRAXANE does not contain solvents, it is not usually necessary to take medicines to prevent allergic reactions before ABRAXANE is given. These medicines are called premedication

It is important to know that allergic reactions can occur with ABRAXANE. Premedication may be needed if you have had an allergic reaction. Allergic reactions may be severe and can lead to death. In case of severe allergic reaction, ABRAXANE should not be used again.

How does ABRAXANE work?

ABRAXANE travels through the bloodstream to reach cells in many parts of the body, including cancer cells.
Illustrative purposes only.

ABRAXANE may help stop cancer cells from dividing and making new cells. ABRAXANE works by blocking the action of proteins called microtubules (MY-kroh-TOO-byools).These proteins help cells divide.
Systemic (sis-TEH-mik) treatments like ABRAXANE are used to treat metastatic (meh-tuh-STA-tik) cancer. This is cancer that has spread from one part of the body to another. It is also known as advanced or stage 4 cancer. Systemic treatments travel through the bloodstream. This makes it possible to reach cells in many parts of the body, including cancer cells. ABRAXANE may also affect normal cells. This may cause side effects.

ABRAXANE travels through the bloodstream to reach cells in many parts of the body, including cancer cells.
Illustrative purposes only.

How does Abraxane for Advanced Breast Cancer Work

How is ABRAXANE given?

ABRAXANE is given by intravenous (IN-truh-VEE-nus), or IV, infusion .
To begin the infusion:

  • A nurse inserts a thin, soft tube into your vein to give the medicine. This is often called an IV. If you have a central line in place, the nurse will use that to give you the medicine
  • ABRAXANE flows through the IV into your bloodstream
  • After each infusion, the nurse removes the IV or the device that delivered the medicines through your central line. Your central line or port stays in place

Advanced Metastatic Breast Cancer Treatment Times
Treatment with ABRAXANE can cause irritation where the medicine is injected (injection site reactions). You should be monitored by your doctor or nurse during and after you receive ABRAXANE to make sure no problems occur at the injection site. In some cases, these problems occurred 7 to 10 days after the medicine was injected.
Your treatment with ABRAXANE will be given in your doctor’s office, at a hospital, or at an infusion center. Each infusion of ABRAXANE takes 30 minutes. Tests, checkups, or waiting time may affect the length of treatment sessions.
Advanced Metastatic Breast Cancer Treatment Times
Advanced Metastatic Breast Cancer Treatment Diary

How often will I be given ABRAXANE?

Metastatic Breast Cancer Treatment Calendar
ABRAXANE is given once every 3 weeks. If you have questions about your treatment schedule, ask your doctor.
Metastatic Breast Cancer Treatment Calendar
Advanced Metastatic Breast Cancer Treatment Diary